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Protein S, Functional
Ordering Recommendation
Acceptable test for detecting protein S deficiency. Preferred test is Protein S Free, Antigen (0098894). Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.
New York DOH Approval Status
Specimen Required
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Transfer 1.5 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum. EDTA plasma, clotted or hemolyzed specimens.
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months
Methodology
Electromagnetic Mechanical Clot Detection
Performed
Sun-Sat
Reported
1-2 days
Reference Interval
Male
1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-5 years: 62-120%
6 years: 62-130%
7-9 years: 66-140%
10-11 years: 65-139%
12-13 years: 72-139%
14-15 years: 68-145%
16-17 years: 77-167%
18 years and older: 66-143%
Female
1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-5 years: 62-120%
6 years: 62-130%
7-9 years: 62-151%
10-11 years: 65-142%
12-13 years: 70-140%
14-15 years: 55-145%
16-17 years: 51-147%
18 years and older: 57-131%
Interpretive Data
Patients on warfarin may have decreased functional protein S values. Patients should be off warfarin therapy for two weeks for accurate measurement of functional protein S. Artificially increased functional protein S values may be due to heparin therapy or the presence of direct thrombin inhibitors or factor Xa inhibitors.
FDA
Note
Hotline History
CPT Codes
85306
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0030114 | Protein S Functional | 27822-6 |
Aliases
- Functional Protein S
- Protein S Activity, Plasma
